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Lifestyle Modifications are crucial in managing diabetes and obesity

Although the existing evidence in HFpEF is compelling, further trials seem warranted, particularly with respect to the effects of GLP-1 RAs on clinical outcomes and, possibly, in broader patient populations, such as patients with HFrEF or those without obesity.

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A low FODMAP diet may alter the exposure of enteroendocrine cells to gut microbial metabolites, leading to altered production of GLP-1

However, its still important to be aware of the potential side effects, which may include: Stomach pain

Starting at the lowest possible dose and escalating more slowly than standard protocols helps identify tolerance issues before reaching problematic dose levels